Investigation of the Structure and Dynamics of the Capsid-Spacer Peptide 1-Nucleocapsid fragment of the HIV-1 Gag Polyprotein by solution NMR spectroscopy()

Structural studies of HIV-1 Gag, the primary structural polyprotein involved in retroviral assembly, have been challenging owing to its flexibility and conformational heterogeneity. Using residual dipolar couplings we show that the four structural units of the capsid (CA)-spacer peptide 1 (SP1)-nucl...

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Hauptverfasser: Deshmukh, Lalit, Ghirlando, Rodolfo, Clore, G. Marius
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4049115/
https://ncbi.nlm.nih.gov/pubmed/24338988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201309127
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