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Targeting a Dark Excited State of HIV-1 Nucleocapsid by Antiretroviral Thioesters Revealed by NMR Spectroscopy

HIV-1 nucleocapsid (NCp7) is a two Cys(2)HisCys zinc knuckle (N-Zn and C-Zn) protein that plays a key role in viral replication. NCp7 conformational dynamics is characterized by NMR relaxation dispersion and chemical exchange saturation transfer measurements. While the N-Zn knuckle is conformational...

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Détails bibliographiques
Publié dans:Angew Chem Int Ed Engl
Auteurs principaux: Deshmukh, Lalit, Tugarinov, Vitali, Appella, Daniel H., Clore, G. Marius
Format: Artigo
Langue:Inglês
Publié: 2018
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6034507/
https://ncbi.nlm.nih.gov/pubmed/29345807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201713172
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