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Targeting a Dark Excited State of HIV-1 Nucleocapsid by Antiretroviral Thioesters Revealed by NMR Spectroscopy
HIV-1 nucleocapsid (NCp7) is a two Cys(2)HisCys zinc knuckle (N-Zn and C-Zn) protein that plays a key role in viral replication. NCp7 conformational dynamics is characterized by NMR relaxation dispersion and chemical exchange saturation transfer measurements. While the N-Zn knuckle is conformational...
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| Publié dans: | Angew Chem Int Ed Engl |
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| Auteurs principaux: | , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2018
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6034507/ https://ncbi.nlm.nih.gov/pubmed/29345807 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201713172 |
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