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Reversal of female infertility by Chk2 ablation reveals the oocyte DNA damage checkpoint pathway
Genetic errors in meiosis can lead to birth defects and spontaneous abortions. Checkpoint mechanisms of hitherto unknown nature eliminate oocytes with unrepaired DNA damage, causing recombination-defective mutant mice to be sterile. Here, we report that checkpoint kinase 2 (Chk2; Chek2), is essentia...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4048839/ https://ncbi.nlm.nih.gov/pubmed/24482479 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1247671 |
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