Recognition of HIV-TAR RNA using Neomycin-Benzimidazole Conjugates

Synthesis of a novel class of compounds and their biophysical studies with TAR-RNA are presented. The synthesis of these compounds was achieved by conjugating neomycin, an aminoglycoside, with benzimidazoles modeled from a B-DNA minor groove binder, Hoechst 33258. The neomycin-benzimidazole conjugat...

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Bibliographic Details
Main Authors: Ranjan, Nihar, Kumar, Sunil, Watkins, Derrick, Wang, Deyun, Appella, Daniel H., Arya, Dev P.
Format: Artigo
Language:Inglês
Published: 2013
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4048829/
https://ncbi.nlm.nih.gov/pubmed/24012122
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2013.08.014
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