ZO-1 and ZO-2 Are Required for Extra-Embryonic Endoderm Integrity, Primitive Ectoderm Survival and Normal Cavitation in Embryoid Bodies Derived from Mouse Embryonic Stem Cells

The Zonula Occludens proteins ZO-1 and ZO-2 are cell-cell junction-associated adaptor proteins that are essential for the structural and regulatory functions of tight junctions in epithelial cells and their absence leads to early embryonic lethality in mouse models. Here, we use the embryoid body, a...

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Detalhes bibliográficos
Main Authors: Phua, Dominic C. Y., Xu, Jianliang, Ali, Safiah Mohamed, Boey, Adrian, Gounko, Natalia V., Hunziker, Walter
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4048262/
https://ncbi.nlm.nih.gov/pubmed/24905925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0099532
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