Fut3-dependent synthesis of sLe(a) on CD44v6 mediates PMN detachment from intestinal epithelium during transepithelial migration

PMN migration across the intestinal epithelium closely parallels disease symptoms in patients with inflammatory bowel disease (IBD). PMN transepithelial migration (TEM) is a multistep process that terminates with PMN detachment from the apical epithelium into the lumen. Using a unique mAb (GM35), we...

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Detalhes bibliográficos
Main Authors: Brazil, Jennifer C., Liu, Renpeng, Sumagin, Ronen, Kolegraff, Keli N., Nusrat, Asma, Cummings, Richard D., Parkos, Charles A., Louis, Nancy A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4047976/
https://ncbi.nlm.nih.gov/pubmed/24068663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1301307
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