Fut3-dependent synthesis of sLe(a) on CD44v6 mediates PMN detachment from intestinal epithelium during transepithelial migration

PMN migration across the intestinal epithelium closely parallels disease symptoms in patients with inflammatory bowel disease (IBD). PMN transepithelial migration (TEM) is a multistep process that terminates with PMN detachment from the apical epithelium into the lumen. Using a unique mAb (GM35), we...

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Bibliographic Details
Main Authors: Brazil, Jennifer C., Liu, Renpeng, Sumagin, Ronen, Kolegraff, Keli N., Nusrat, Asma, Cummings, Richard D., Parkos, Charles A., Louis, Nancy A.
Format: Artigo
Language:Inglês
Published: 2013
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4047976/
https://ncbi.nlm.nih.gov/pubmed/24068663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1301307
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