Combined PDK1 and CHK1 inhibition is required to kill glioblastoma stem-like cells in vitro and in vivo

Glioblastoma (GBM) is the most common and deadly adult brain tumor. Despite aggressive surgery, radiation, and chemotherapy, the life expectancy of patients diagnosed with GBM is ∼14 months. The extremely aggressive nature of GBM results from glioblastoma stem-like cells (GSCs) that sustain GBM grow...

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Detalhes bibliográficos
Main Authors: Signore, M, Pelacchi, F, di Martino, S, Runci, D, Biffoni, M, Giannetti, S, Morgante, L, De Majo, M, Petricoin, E F, Stancato, L, Larocca, L M, De Maria, R, Pallini, R, Ricci-Vitiani, L
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4047898/
https://ncbi.nlm.nih.gov/pubmed/24810059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2014.188
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