A highly cytotoxic modified paullone ligand bearing a TEMPO free-radical unit and its copper(ii) complex as potential hR2 RNR inhibitors

A new paullone–TEMPO conjugate and its copper(ii) complex inhibit RNR activity and show high antiproliferative activity in human cancer cell lines.

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Detalhes bibliográficos
Main Authors: Dobrov, Anatolie, Göschl, Simone, Jakupec, Michael A., Popović-Bijelić, Ana, Gräslund, Astrid, Rapta, Peter, Arion, Vladimir B.
Formato: Artigo
Idioma:Inglês
Publicado em: Royal Society of Chemistry 2013
Assuntos:
Chemistry
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4047831/
https://ncbi.nlm.nih.gov/pubmed/24042148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c3cc45743e
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