Coumarin-Based Triapine Derivatives and Their Copper(II) Complexes: Synthesis, Cytotoxicity and mR2 RNR Inhibition Activity

A series of thiosemicarbazone-coumarin hybrids (HL(1)-HL(3) and H(2)L(4)) has been synthesised in 12 steps and used for the preparation of mono- and dinuclear copper(II) complexes, namely Cu(HL(1))Cl(2) (1), Cu(HL(2))Cl(2) (2), Cu(HL(3))Cl(2) (3) and Cu(2)(H(2)L(4))Cl(4) (4), isolated in hydrated or...

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Publicado no:Biomolecules
Main Authors: Stepanenko, Iryna, Babak, Maria V., Spengler, Gabriella, Hammerstad, Marta, Popovic-Bijelic, Ana, Shova, Sergiu, Büchel, Gabriel E., Darvasiova, Denisa, Rapta, Peter, Arion, Vladimir B.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8230303/
https://ncbi.nlm.nih.gov/pubmed/34207929
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biom11060862
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