Biological activity of ruthenium and osmium arene complexes with modified paullones in human cancer cells

In an attempt to combine the ability of indolobenzazepines (paullones) to inhibit cyclin-dependent kinases (Cdks) and that of platinum-group metal ions to interact with proteins and DNA, ruthenium(II) and osmium(II) arene complexes with paullones were prepared, expecting synergies and an increase of...

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Hauptverfasser: Mühlgassner, Gerhard, Bartel, Caroline, Schmid, Wolfgang F., Jakupec, Michael A., Arion, Vladimir B., Keppler, Bernhard K.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3492762/
https://ncbi.nlm.nih.gov/pubmed/23037896
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jinorgbio.2012.06.003
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