Inefficient Translocation of Preproinsulin Contributes to Pancreatic β Cell Failure and Late-onset Diabetes

Among the defects in the early events of insulin biosynthesis, proinsulin misfolding and endoplasmic reticulum (ER) stress have drawn increasing attention as causes of β cell failure. However, no studies have yet addressed potential defects at the cytosolic entry point of preproinsulin into the secr...

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Hlavní autoři: Guo, Huan, Xiong, Yi, Witkowski, Piotr, Cui, Jingqing, Wang, Ling-jia, Sun, Jinhong, Lara-Lemus, Roberto, Haataja, Leena, Hutchison, Kathryn, Shan, Shu-ou, Arvan, Peter, Liu, Ming
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2014
Témata:
Molecular Bases of Disease
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4047398/
https://ncbi.nlm.nih.gov/pubmed/24770419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.562355
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