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Acidic Amino Acids in the First Intracellular Loop Contribute to Voltage- and Calcium- Dependent Gating of Anoctamin1/TMEM16A

Anoctamin1 (Ano1, or TMEM16A) is a Ca(2+)-activated chloride channel that is gated by both voltage and Ca(2+). We have previously identified that the first intracellular loop that contains a high density of acidic residues mediates voltage- and calcium-dependent gating of Ano1. Mutation of the four...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Xiao, Qinghuan, Cui, Yuanyuan
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2014
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4047086/
https://ncbi.nlm.nih.gov/pubmed/24901998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0099376
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