A High Through-Put Screen for Small Molecules Modulating MCM2 Phosphorylation Identifies Ryuvidine as an Inducer of the DNA Damage Response

DNA replication is an essential process for cell division and as such it is a process that is directly targeted by several anticancer drugs. CDC7 plays an essential role in the activation of replication origins and has recently been proposed as a novel target for drug discovery. The MCM DNA helicase...

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Detalhes bibliográficos
Main Authors: FitzGerald, Jennifer, Murillo, Laura S., O'Brien, Gemma, O'Connell, Enda, O'Connor, Aisling, Wu, Kevin, Wang, Guan-Nan, Rainey, Michael D., Natoni, Alessandro, Healy, Sandra, O'Dwyer, Michael, Santocanale, Corrado
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4047068/
https://ncbi.nlm.nih.gov/pubmed/24902048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0098891
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