Genetic Background Drives Transcriptional Variation in Human Induced Pluripotent Stem Cells

Human iPS cells have been generated using a diverse range of tissues from a variety of donors using different reprogramming vectors. However, these cell lines are heterogeneous, which presents a limitation for their use in disease modeling and personalized medicine. To explore the basis of this hete...

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Bibliographic Details
Main Authors: Rouhani, Foad, Kumasaka, Natsuhiko, de Brito, Miguel Cardoso, Bradley, Allan, Vallier, Ludovic, Gaffney, Daniel
Format: Artigo
Language:Inglês
Published: Public Library of Science 2014
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4046971/
https://ncbi.nlm.nih.gov/pubmed/24901476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1004432
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