Intracellular mRNA Regulation with Self-Assembled Locked Nucleic Acid Polymer Nanoparticles

[Image: see text] We present an untemplated, single-component antisense oligonucleotide delivery system capable of regulating mRNA abundance in live human cells. While most approaches to nucleic acid delivery rely on secondary carriers and complex multicomponent charge-neutralizing formulations, we...

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Detalhes bibliográficos
Main Authors: Rush, Anthony M., Nelles, David A., Blum, Angela P., Barnhill, Sarah A., Tatro, Erick T., Yeo, Gene W., Gianneschi, Nathan C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4046771/
https://ncbi.nlm.nih.gov/pubmed/24827740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja503598z
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