Accurate detection of subclonal single nucleotide variants in whole genome amplified and pooled cancer samples using HaloPlex target enrichment

BACKGROUND: Target enrichment and resequencing is a widely used approach for identification of cancer genes and genetic variants associated with diseases. Although cost effective compared to whole genome sequencing, analysis of many samples constitutes a significant cost, which could be reduced by p...

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Main Authors: Berglund, Eva C, Lindqvist, Carl Mårten, Hayat, Shahina, Övernäs, Elin, Henriksson, Niklas, Nordlund, Jessica, Wahlberg, Per, Forestier, Erik, Lönnerholm, Gudmar, Syvänen, Ann-Christine
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2013
Fag:
Methodology Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4046713/
https://ncbi.nlm.nih.gov/pubmed/24314227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2164-14-856
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