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Accumulation of CTCF-binding sites drives expression divergence between tandemly duplicated genes in humans

BACKGROUND: During eukaryotic genome evolution, tandem gene duplication is the most frequent event giving rise to clustered gene families. However, how expression divergence between tandemly duplicated genes has emerged and maintained remain unclear. In particular, it is unknown if epigenetic regula...

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Bibliographic Details
Main Authors: Liao, Ben-Yang, Chang, Andrew Ying-Fei
Format: Artigo
Language:Inglês
Published: BioMed Central 2014
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4046690/
https://ncbi.nlm.nih.gov/pubmed/24564680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2164-15-S1-S8
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