Breast cancer and metabolic syndrome linked through the plasminogen activator inhibitor-1 cycle

Plasminogen activator inhibitor-1 (PAI-1) is a physiological inhibitor of urokinase (uPA), a serine protease known to promote cell migration and invasion. Intuitively, increased levels of PAI-1 should be beneficial in down-regulating uPA activity, particularly in cancer. By contrast, in vivo, increa...

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Autori principali: Beaulieu, Lea M., Whitley, Brandi R., Wiesner, Theodore F., Rehault, Sophie M., Palmieri, Diane, Elkahloun, Abdel G., Church, Frank C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2007
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4046619/
https://ncbi.nlm.nih.gov/pubmed/17876797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bies.20640
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