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Plasminogen Activator Inhibitor-1 is an Aggregate Response Factor with Pleiotropic Effects on Cell Signaling in Vascular Disease and the Tumor Microenvironment
In hemostasis, the serine protease inhibitor (serpin) plasminogen activator inhibitor-1 (PAI-1) functions to stabilize clots via inhibition of tissue plasminogen activator (tPA) with subsequent inhibition of fibrinolysis. In tissues, PAI-1 functions to inhibit extracellular matrix degradation via in...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2860057/ https://ncbi.nlm.nih.gov/pubmed/20079523 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.thromres.2009.11.034 |
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