MLN4924, an NAE inhibitor, suppresses AKT and mTOR signaling via upregulation of REDD1 in human myeloma cells

The function and survival of normal and malignant plasma cells depends on the elaborately regulated ubiquitin proteasome system. Proteasome inhibitors such as bortezomib have proved to be highly effective in the treatment of multiple myeloma (MM), and their effects are related to normal protein home...

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Main Authors: Gu, Yanyan, Kaufman, Jonathan L., Bernal, Leon, Torre, Claire, Matulis, Shannon M., Harvey, R. Donald, Chen, Jing, Sun, Shi-Yong, Boise, Lawrence H., Lonial, Sagar
Formato: Artigo
Idioma:Inglês
Publicado: American Society of Hematology 2014
Assuntos:
Lymphoid Neoplasia
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4046434/
https://ncbi.nlm.nih.gov/pubmed/24713927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2013-08-521914
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