Structural basis for diverse N-glycan recognition by HIV-1–neutralizing V1–V2–directed antibody PG16

HIV-1 uses a diverse N-linked-glycan shield to evade recognition by antibody. Select human antibodies, such as the clonally related PG9 and PG16, recognize glycopeptide epitopes in the HIV-1 V1–V2 region and penetrate this shield, but their ability to accommodate diverse glycans is unclear. Here we...

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Main Authors: Pancera, Marie, Shahzad-ul-Hussan, Syed, Doria-Rose, Nicole A, McLellan, Jason S, Bailer, Robert T, Dai, Kaifan, Loesgen, Sandra, Louder, Mark K, Staupe, Ryan P, Yang, Yongping, Zhang, Baoshan, Parks, Robert, Eudailey, Joshua, Lloyd, Krissey E, Blinn, Julie, Alam, S Munir, Haynes, Barton F, Amin, Mohammed N, Wang, Lai-Xi, Burton, Dennis R, Koff, Wayne C, Nabel, Gary J, Mascola, John R, Bewley, Carole A, Kwong, Peter D
Format: Artigo
Language:Inglês
Published: 2013
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4046252/
https://ncbi.nlm.nih.gov/pubmed/23708607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2600
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