Hck contributes to bone homeostasis by controlling the recruitment of osteoclast precursors

In osteoclasts, Src controls podosome organization and bone degradation, which leads to an osteopetrotic phenotype in src(−/−) mice. Since this phenotype was even more severe in src(−/−)hck(−)(/)(−) mice, we examined the individual contribution of Hck in bone homeostasis. Compared to wt mice, hck(−/...

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Main Authors: Vérollet, Christel, Gallois, Anne, Dacquin, Romain, Lastrucci, Claire, Pandruvada, Subramanya N. M., Ortega, Nathalie, Poincloux, Renaud, Behar, Annie, Cougoule, Céline, Lowell, Clifford, Al Saati, Talal, Jurdic, Pierre, Maridonneau-Parini, Isabelle
Formato: Artigo
Idioma:Inglês
Publicado: Federation of American Societies for Experimental Biology 2013
Assuntos:
Research Communications
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4046168/
https://ncbi.nlm.nih.gov/pubmed/23742809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.13-232736
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