Effect of Cyp27A1 gene dosage on atherosclerosis development in ApoE-knockout mice

In humans, sterol 27-hydroxylase (CYP27A1) deficiency leads to cholesterol deposition in tendons and vasculature. Thus, in addition to its role in bile acid synthesis, where it converts cholesterol to 27-hydroxycholesterol (27-OHC), CYP27A1 may also be atheroprotective. Cyp27A1-deficient (Cyp27A1(−/...

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Bibliografiske detaljer
Main Authors: Zurkinden, Line, Solcà, Curzio, Vögeli, Isabelle A., Vogt, Bruno, Ackermann, Daniel, Erickson, Sandra K., Frey, Felix J., Sviridov, Dmitri, Escher, Geneviève
Format: Artigo
Sprog:Inglês
Udgivet: Federation of American Societies for Experimental Biology 2014
Fag:
Research Communications
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4046167/
https://ncbi.nlm.nih.gov/pubmed/24327605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.13-233791
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