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Catalytic Activity of cGMP-Dependent Protein Kinase Type I in Intact Cells Is Independent of N-Terminal Autophosphorylation

Although cGMP-dependent protein kinase type I (cGKI) is an important mediator of cGMP signaling and upcoming drug target, its in vivo-biochemistry is not well understood. Many studies showed that purified cGKI autophosphorylates multiple sites at its N-terminus. Autophosphorylation might be involved...

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Detalhes bibliográficos
Main Authors: Vallur, Raghavan, Kalbacher, Hubert, Feil, Robert
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4045857/
https://ncbi.nlm.nih.gov/pubmed/24897423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0098946
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