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Kinetic isotope effects significantly influence intracellular metabolite (13)C labeling patterns and flux determination

Rigorous mathematical modeling of carbon-labeling experiments allows estimation of fluxes through the pathways of central carbon metabolism, yielding powerful information for basic scientific studies as well as for a wide range of applications. However, the mathematical models that have been develop...

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Bibliographic Details
Main Authors: Wasylenko, Thomas M., Stephanopoulos, Gregory
Format: Artigo
Language:Inglês
Published: 2013
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4045492/
https://ncbi.nlm.nih.gov/pubmed/23828762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/biot.201200276
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