A mouse model for beta 0-thalassemia.

We have used a "plug and socket" targeting technique to generate a mouse model of beta 0-thalassemia in which both the b1 and b2 adult globin genes have been deleted. Mice homozygous for this deletion (Hbbth-3/Hbbth-3) die perinatally, similar to the most severe form of Cooley anemia in hu...

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Bibliografiska uppgifter
Huvudupphovsmän: Yang, B, Kirby, S, Lewis, J, Detloff, P J, Maeda, N, Smithies, O
Materialtyp: Artigo
Språk:Inglês
Publicerad: 1995
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC40451/
https://ncbi.nlm.nih.gov/pubmed/8524813
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