MRI evaluation of BBB disruption after adjuvant AcSDKP treatment of stroke with tPA in rat

The primary limitation of thrombolytic treatment of ischemic stroke with tPA is the hemorrhagic risk. We tested AcSDKP (N-acetyl-seryl-aspartyl-lysyl-proline), as an auxiliary therapeutic agent, to reduce blood-brain barrier (BBB) disruption in a combination tPA thrombolytic treatment of stroke. Wis...

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Bibliographic Details
Main Authors: Ding, Guangliang, Zhang, Zhenggang, Chopp, Michael, Li, Lian, Zhang, Li, Li, Qingjiang, Wei, Min, Jiang, Quan
Format: Artigo
Language:Inglês
Published: 2014
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4044825/
https://ncbi.nlm.nih.gov/pubmed/24769225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuroscience.2014.04.025
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