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MRI evaluation of BBB disruption after adjuvant AcSDKP treatment of stroke with tPA in rat

The primary limitation of thrombolytic treatment of ischemic stroke with tPA is the hemorrhagic risk. We tested AcSDKP (N-acetyl-seryl-aspartyl-lysyl-proline), as an auxiliary therapeutic agent, to reduce blood-brain barrier (BBB) disruption in a combination tPA thrombolytic treatment of stroke. Wis...

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Bibliografiske detaljer
Main Authors: Ding, Guangliang, Zhang, Zhenggang, Chopp, Michael, Li, Lian, Zhang, Li, Li, Qingjiang, Wei, Min, Jiang, Quan
Format: Artigo
Sprog:Inglês
Udgivet: 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4044825/
https://ncbi.nlm.nih.gov/pubmed/24769225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuroscience.2014.04.025
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