In Vivo Synthesis of Mammalian-Like, Hybrid-Type N-Glycans in Pichia pastoris

The Pichia pastoris N-glycosylation pathway is only partially homologous to the pathway in human cells. In the Golgi apparatus, human cells synthesize complex oligosaccharides, whereas Pichia cells form mannose structures that can contain up to 40 mannose residues. This hypermannosylation of secrete...

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Bibliografiske detaljer
Udgivet i:Appl Environ Microbiol
Main Authors: Vervecken, Wouter, Kaigorodov, Vladimir, Callewaert, Nico, Geysens, Steven, De Vusser, Kristof, Contreras, Roland
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2004
Fag:
Physiology and Biotechnology
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC404441/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15128513/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AEM.70.5.2639-2646.2004
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