In Vivo Synthesis of Mammalian-Like, Hybrid-Type N-Glycans in Pichia pastoris

The Pichia pastoris N-glycosylation pathway is only partially homologous to the pathway in human cells. In the Golgi apparatus, human cells synthesize complex oligosaccharides, whereas Pichia cells form mannose structures that can contain up to 40 mannose residues. This hypermannosylation of secrete...

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Autors principals: Vervecken, Wouter, Kaigorodov, Vladimir, Callewaert, Nico, Geysens, Steven, De Vusser, Kristof, Contreras, Roland
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2004
Matèries:
Physiology and Biotechnology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC404441/
https://ncbi.nlm.nih.gov/pubmed/15128513
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.70.5.2639-2646.2004
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