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In Vivo Synthesis of Mammalian-Like, Hybrid-Type N-Glycans in Pichia pastoris

The Pichia pastoris N-glycosylation pathway is only partially homologous to the pathway in human cells. In the Golgi apparatus, human cells synthesize complex oligosaccharides, whereas Pichia cells form mannose structures that can contain up to 40 mannose residues. This hypermannosylation of secrete...

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Détails bibliographiques
Publié dans:Appl Environ Microbiol
Auteurs principaux: Vervecken, Wouter, Kaigorodov, Vladimir, Callewaert, Nico, Geysens, Steven, De Vusser, Kristof, Contreras, Roland
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology (ASM) 2004
Sujets:
Accès en ligne:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC404441/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15128513/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AEM.70.5.2639-2646.2004
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