In Vivo Synthesis of Mammalian-Like, Hybrid-Type N-Glycans in Pichia pastoris

The Pichia pastoris N-glycosylation pathway is only partially homologous to the pathway in human cells. In the Golgi apparatus, human cells synthesize complex oligosaccharides, whereas Pichia cells form mannose structures that can contain up to 40 mannose residues. This hypermannosylation of secrete...

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Pubblicato in:	Appl Environ Microbiol
Autori principali:	Vervecken, Wouter, Kaigorodov, Vladimir, Callewaert, Nico, Geysens, Steven, De Vusser, Kristof, Contreras, Roland
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 2004
Soggetti:	Physiology and Biotechnology
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC404441/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15128513/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AEM.70.5.2639-2646.2004
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In Vivo Synthesis of Mammalian-Like, Hybrid-Type N-Glycans in Pichia pastoris

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