Genetic Modulation of Soluble Aβ Rescues Cognitive and Synaptic Impairment in a Mouse Model of Alzheimer's Disease

An unresolved debate in Alzheimer's disease (AD) is whether amyloid plaques are pathogenic, causing overt physical disruption of neural circuits, or protective, sequestering soluble forms of amyloid-β (Aβ) that initiate synaptic damage and cognitive decline. Few animal models of AD have been ca...

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Detaylı Bibliyografya
Asıl Yazarlar: Fowler, Stephanie W., Chiang, Angie C. A., Savjani, Ricky R., Larson, Megan E., Sherman, Mathew A., Schuler, Dorothy R., Cirrito, John R., Lesné, Sylvain E., Jankowsky, Joanna L.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Society for Neuroscience 2014
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Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4044248/
https://ncbi.nlm.nih.gov/pubmed/24899710
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0572-14.2014
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