Genetic Modulation of Soluble Aβ Rescues Cognitive and Synaptic Impairment in a Mouse Model of Alzheimer's Disease

An unresolved debate in Alzheimer's disease (AD) is whether amyloid plaques are pathogenic, causing overt physical disruption of neural circuits, or protective, sequestering soluble forms of amyloid-β (Aβ) that initiate synaptic damage and cognitive decline. Few animal models of AD have been ca...

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Главные авторы: Fowler, Stephanie W., Chiang, Angie C. A., Savjani, Ricky R., Larson, Megan E., Sherman, Mathew A., Schuler, Dorothy R., Cirrito, John R., Lesné, Sylvain E., Jankowsky, Joanna L.
Формат: Artigo
Язык:Inglês
Опубликовано: Society for Neuroscience 2014
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4044248/
https://ncbi.nlm.nih.gov/pubmed/24899710
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0572-14.2014
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