Genetic Modulation of Soluble Aβ Rescues Cognitive and Synaptic Impairment in a Mouse Model of Alzheimer's Disease

An unresolved debate in Alzheimer's disease (AD) is whether amyloid plaques are pathogenic, causing overt physical disruption of neural circuits, or protective, sequestering soluble forms of amyloid-β (Aβ) that initiate synaptic damage and cognitive decline. Few animal models of AD have been ca...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Fowler, Stephanie W., Chiang, Angie C. A., Savjani, Ricky R., Larson, Megan E., Sherman, Mathew A., Schuler, Dorothy R., Cirrito, John R., Lesné, Sylvain E., Jankowsky, Joanna L.
Médium: Artigo
Jazyk:Inglês
Vydáno: Society for Neuroscience 2014
Témata:
Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4044248/
https://ncbi.nlm.nih.gov/pubmed/24899710
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0572-14.2014
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky