Quinoxaline-substituted chalcones as new inhibitors of breast cancer resistance protein ABCG2: polyspecificity at B-ring position

A series of chalcones substituted by a quinoxaline unit at the B-ring were synthesized and tested as inhibitors of breast cancer resistance protein-mediated mitoxantrone efflux. These compounds appeared more efficient than analogs containing other B-ring substituents such as 2-naphthyl or 3,4-methyl...

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Detalhes bibliográficos
Main Authors: Winter, Evelyn, Gozzi, Gustavo Jabor, Chiaradia-Delatorre, Louise Domeneghini, Daflon-Yunes, Nathalia, Terreux, Raphael, Gauthier, Charlotte, Mascarello, Alessandra, Leal, Paulo César, Cadena, Silvia M, Yunes, Rosendo Augusto, Nunes, Ricardo José, Creczynski-Pasa, Tania Beatriz, Di Pietro, Attilio
Formato: Artigo
Idioma:Inglês
Publicado em: Dove Medical Press 2014
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4043709/
https://ncbi.nlm.nih.gov/pubmed/24920885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S56625
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