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Structure of the polyketide cyclase SnoaL reveals a novel mechanism for enzymatic aldol condensation
SnoaL belongs to a family of small polyketide cyclases, which catalyse ring closure steps in the biosynthesis of polyketide antibiotics produced in Streptomyces. Several of these antibiotics are among the most used anti-cancer drugs currently in use. The crystal structure of SnoaL, involved in nogal...
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| Hauptverfasser: | , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Nature Publishing Group
2004
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC404321/ https://ncbi.nlm.nih.gov/pubmed/15071504 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600201 |
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