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Structure of the polyketide cyclase SnoaL reveals a novel mechanism for enzymatic aldol condensation
SnoaL belongs to a family of small polyketide cyclases, which catalyse ring closure steps in the biosynthesis of polyketide antibiotics produced in Streptomyces. Several of these antibiotics are among the most used anti-cancer drugs currently in use. The crystal structure of SnoaL, involved in nogal...
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| Hlavní autoři: | , , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Nature Publishing Group
2004
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC404321/ https://ncbi.nlm.nih.gov/pubmed/15071504 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600201 |
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