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Tetraphenylporphyrin derivative specifically blocks members of the voltage-gated potassium channel subfamily Kv1

Tetraphenylporphyrin derivatives represent a promising class of high-affinity ligands for voltage-gated potassium (Kv) channels. Herein, we investigated the mode of Kv channel block of one tetraphenylporphyrin derivative, por3, using electrophysiological methods, structure-based mutagenesis, and sol...

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Hlavní autoři: Hornig, Sönke, Ohmert, Iris, Trauner, Dirk, Ader, Christian, Baldus, Marc, Pongs, Olaf
Médium: Artigo
Jazyk:Inglês
Vydáno: Landes Bioscience 2013
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4042482/
https://ncbi.nlm.nih.gov/pubmed/24722265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/chan.25848
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