Coupling of activation and inactivation gate in a K(+)-channel: potassium and ligand sensitivity

Potassium (K(+))-channel gating is choreographed by a complex interplay between external stimuli, K(+) concentration and lipidic environment. We combined solid-state NMR and electrophysiological experiments on a chimeric KcsA–Kv1.3 channel to delineate K(+), pH and blocker effects on channel structu...

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Autori principali: Ader, Christian, Schneider, Robert, Hornig, Sönke, Velisetty, Phanindra, Vardanyan, Vitya, Giller, Karin, Ohmert, Iris, Becker, Stefan, Pongs, Olaf, Baldus, Marc
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2009
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2750023/
https://ncbi.nlm.nih.gov/pubmed/19661921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2009.218
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