Enhanced somatic mutation rates induced in stem cells of mice by low chronic exposure to ethylnitrosourea.

We have found that the somatic mutation rate at the Dlb-1 locus increases exponentially during low daily exposure to ethylnitrosourea over 4 months. This effect, enhanced mutagenesis, was not observed at a lacI transgene in the same tissue, although the two loci respond very similarly to acute doses...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Shaver-Walker, P M, Urlando, C, Tao, K S, Zhang, X B, Heddle, J A
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1995
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC40423/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8524785/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.25.11470
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