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Mechanism of Siglec-8-mediated Cell Death in IL-5-activated Eosinophils: Role for ROS-enhanced MEK/ERK Activation
BACKGROUND: Siglec-8 is expressed on human eosinophils, where its ligation induces cell death. Paradoxically, Siglec-8-mediated cell death is markedly enhanced by the presence of the activation and survival factor IL-5 and becomes independent of caspase activity. OBJECTIVE: In this report we investi...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4042061/ https://ncbi.nlm.nih.gov/pubmed/23684072 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2013.03.024 |
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