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Mechanism of Siglec-8-mediated Cell Death in IL-5-activated Eosinophils: Role for ROS-enhanced MEK/ERK Activation

BACKGROUND: Siglec-8 is expressed on human eosinophils, where its ligation induces cell death. Paradoxically, Siglec-8-mediated cell death is markedly enhanced by the presence of the activation and survival factor IL-5 and becomes independent of caspase activity. OBJECTIVE: In this report we investi...

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Библиографические подробности
Главные авторы: Kano, Gen, Almanan, Maha, Bochner, Bruce S., Zimmermann, Nives
Формат: Artigo
Язык:Inglês
Опубликовано: 2013
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4042061/
https://ncbi.nlm.nih.gov/pubmed/23684072
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2013.03.024
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