Identification of a hexapeptide inhibitor of the human immunodeficiency virus integrase protein by using a combinatorial chemical library.

Integration of human immunodeficiency virus (HIV) DNA into the human genome requires the virus-encoded integrase (IN) protein, and therefore the IN protein is a suitable target for antiviral strategies. To find a potent HIV IN inhibitor, we screened a "synthetic peptide combinatorial library." We id...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Puras Lutzke, R A, Eppens, N A, Weber, P A, Houghten, R A, Plasterk, R H
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 1995
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC40420/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8524782/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.25.11456
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