Generation of Replication-Proficient Influenza Virus NS1 Point Mutants with Interferon-Hyperinducer Phenotype

The NS1 protein of influenza A viruses is the dedicated viral interferon (IFN)-antagonist. Viruses lacking NS1 protein expression cannot multiply in normal cells but are viable in cells deficient in their ability to produce or respond to IFN. Here we report an unbiased mutagenesis approach to identi...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Pérez-Cidoncha, Maite, Killip, Marian J., Asensio, Víctor J., Fernández, Yolanda, Bengoechea, José A., Randall, Richard E., Ortín, Juan
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2014
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4041880/
https://ncbi.nlm.nih.gov/pubmed/24887174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0098668
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge