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Differential Effects of Omeprazole and Lansoprazole Enantiomers on Aryl Hydrocarbon Receptor in Human Hepatocytes and Cell Lines

Proton pump inhibitors omeprazole and lansoprazole contain chiral sulfur atom and they are administered as a racemate, i.e. equimolar mixture of S- and R-enantiomers. The enantiopure drugs esomeprazole and dexlansoprazole have been developed and introduced to clinical practice due to their improved...

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Autors principals: Novotna, Aneta, Srovnalova, Alzbeta, Svecarova, Michaela, Korhonova, Martina, Bartonkova, Iveta, Dvorak, Zdenek
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2014
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4041848/
https://ncbi.nlm.nih.gov/pubmed/24887303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0098711
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