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Differential Effects of Omeprazole and Lansoprazole Enantiomers on Aryl Hydrocarbon Receptor in Human Hepatocytes and Cell Lines

Proton pump inhibitors omeprazole and lansoprazole contain chiral sulfur atom and they are administered as a racemate, i.e. equimolar mixture of S- and R-enantiomers. The enantiopure drugs esomeprazole and dexlansoprazole have been developed and introduced to clinical practice due to their improved...

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Bibliografiske detaljer
Main Authors: Novotna, Aneta, Srovnalova, Alzbeta, Svecarova, Michaela, Korhonova, Martina, Bartonkova, Iveta, Dvorak, Zdenek
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4041848/
https://ncbi.nlm.nih.gov/pubmed/24887303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0098711
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