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Calcuim signaling and mitochondrial destabilization in the triggering of the NLRP3 inflammasome
The NLRP3 inflammasome is a cytosolic complex that activates Caspase-1, leading to maturation of IL-1β and IL-18 and induction of a pro-inflammatory cell death in sentinel cells of the innate immune system. Diverse stimuli have been shown to activate the NLRP3 inflammasome during infection and metab...
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4041823/ https://ncbi.nlm.nih.gov/pubmed/24646829 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.it.2014.02.007 |
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