A Non-Canonical NRPS Is Involved in the Synthesis of Fungisporin and Related Hydrophobic Cyclic Tetrapeptides in Penicillium chrysogenum

The filamentous fungus Penicillium chrysogenum harbors an astonishing variety of nonribosomal peptide synthetase genes, which encode proteins known to produce complex bioactive metabolites from simple building blocks. Here we report a novel non-canonical tetra-modular nonribosomal peptide synthetase...

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Autors principals: Ali, Hazrat, Ries, Marco I., Lankhorst, Peter P., van der Hoeven, Rob A. M., Schouten, Olaf L., Noga, Marek, Hankemeier, Thomas, van Peij, Noël N. M. E., Bovenberg, Roel A. L., Vreeken, Rob J., Driessen, Arnold J. M.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2014
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4041764/
https://ncbi.nlm.nih.gov/pubmed/24887561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0098212
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