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Opposing impact of B cell intrinsic TLR7 and TLR9 signals on autoantibody repertoire and systemic inflammation

Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease characterized by autoantibodies targeting nucleic acid-associated antigens. The endosomal toll-like receptors TLR7 and TLR9 are critical for generation of Abs targeting RNA- or DNA-associated antigens, respectively. In murine lup...

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Библиографические подробности
Главные авторы: Jackson, Shaun W., Scharping, Nicole E., Kolhatkar, Nikita S., Khim, Socheath, Schwartz, Marc A., Li, Quan-Zhen, Hudkins, Kelly L., Alpers, Charles E., Liggitt, Denny, Rawlings, David J.
Формат: Artigo
Язык:Inglês
Опубликовано: 2014
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4041708/
https://ncbi.nlm.nih.gov/pubmed/24711620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1400098
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