WASp-deficient B cells play a critical, cell-intrinsic role in triggering autoimmunity

Patients with the immunodeficiency Wiskott-Aldrich syndrome (WAS) frequently develop systemic autoimmunity. Here, we demonstrate that mutation of the WAS gene results in B cells that are hyperresponsive to B cell receptor and Toll-like receptor (TLR) signals in vitro, thereby promoting a B cell–intr...

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Main Authors: Becker-Herman, Shirly, Meyer-Bahlburg, Almut, Schwartz, Marc A., Jackson, Shaun W., Hudkins, Kelly L., Liu, Chaohong, Sather, Blythe D., Khim, Socheath, Liggitt, Denny, Song, Wenxia, Silverman, Gregg J., Alpers, Charles E., Rawlings, David J.
Formato: Artigo
Idioma:Inglês
Publicado: The Rockefeller University Press 2011
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3182055/
https://ncbi.nlm.nih.gov/pubmed/21875954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20110200
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